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Pd/C-catalyzed heterocyclization during copper-free Sonogashira coupling: synthesis of 2-benzylimidazo[1,2-a]pyrimidines in water |
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| Authors: | Mohammad Bakherad Ali KeivanlooZahra Kalantar Saeideh Jajarmi |
| Institution: | School of Chemistry, Shahrood University of Technology, Shahrood, Iran |
| Abstract: | An efficient synthesis of 2-benzylimidazo1,2-a]pyrimidines in water is accomplished via Pd/C-catalyzed reaction of 2-imino-1-(2-propynyl)pyrimidine with various aryl iodides in the presence of K2CO3 as the base. |
| Keywords: | Pd/C-catalyzed Sonogashira reaction Aryl iodide Imidazopyrimidine |
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