Direct organocatalytic hydroalkoxylation of α,β-unsaturated ketones |
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Authors: | Dhevalapally B. Ramachary Rumpa Mondal |
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Affiliation: | School of Chemistry, University of Hyderabad, Central University (P.O.), Hyderabad 500 046, India |
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Abstract: | The direct addition of a variety of alcohols to in situ activated olefins was observed in the presence of mild bifunctional amine/acid catalysts. Unlike existing methods, the reactions proceed at room temperature and in the absence of transition metals. The use of simple commercially available catalysts, amines and acids makes this an attractive method for the preparation of β-alkoxy ketones, which are prevalent targets and intermediates in organic synthesis. |
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Keywords: | Amino acids Amine/acid catalysts Enones Hydroalkoxylation Organocatalysis |
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