New copper-mediated O-arylations of phenols with arylstannanes |
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| Authors: | Alexandros Vakalopoulos Xanthoula Kavazoudi Joachim Schoof |
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| Institution: | Bayer HealthCare AG, Bayer Schering Pharma, Global Drug Discovery, Chemistry Research, D-42096 Wuppertal, Germany |
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| Abstract: | A novel method for the synthesis of diaryl ethers with phenols and arylstannanes under mild conditions is described. This copper-mediated O-arylation is feasible using DMAP in acetonitrile and is complementary to the use of boronic acids as aryl donors. The reaction is tolerant of a wide range of substituents and sterically hindered coupling partners. |
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| Keywords: | Synthesis of diaryl ethers O-Arylation Cross-coupling Copper |
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