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Microwave-assisted one-pot synthesis of substituted tetrahydrocarbazole and 8,9,10,11-tetrahydro-7H-pyrido[a]carbazoles
Authors:Vera Barbieri
Affiliation:Department of Pharmaceutical Sciences, Faculty of Pharmacy, University of Padova, Via Marzolo 5, 35131 Padova, Italy
Abstract:One-pot synthesis of one-substituted tetrahydrocarbazole and 4-substituted 8,9,10,11-tetrahydro-7H-pyrido[a]carbazoles from substituted quinolinylhydrazines and cyclohexanone in acetic acid was performed by microwave irradiation in a controlled temperature with simultaneous cooling system in closed vessel. The optimization procedures of process variables, power, temperature, and irradiation time are reported in detail, and the results from microwave processes are compared with conventional ones.
Keywords:Microwave indole synthesis   Tetrahydrocarbazole   Tetrahydropyridocarbazole
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