Enzymatic formation of an unnatural methylated triketide by plant type III polyketide synthases |
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Authors: | Tsuyoshi Abe Hiroshi Noguchi |
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Institution: | a School of Pharmaceutical Sciences and the 21st Century COE Program, University of Shizuoka, 52-1 Yada, Shizuoka 422-8526, Japan b PRESTO, Japan Science and Technology Agency, Kawaguchi, Saitama 332-0012, Japan |
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Abstract: | Octaketide synthase, a novel plant-specific type III polyketide synthase from Aloe arborescens, efficiently accepted (2RS)-methylmalonyl-CoA as a sole substrate to produce 6-ethyl-4-hydroxy-3,5-dimethyl-2-pyrone. On the other hand, a tetraketide-producing chalcone synthase from Scutellaria baicalensis and a diketide-producing benzalacetone synthase from Rheum palmatum also yielded the unnatural methylated C9 triketide pyrone as a single product by sequential decarboxylative condensations of three molecules of (2RS)-methylmalonyl-CoA. |
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Keywords: | Type III polyketide synthase Chalcone synthase Octaketide synthase Benzalacetone synthase Methylated triketide pyrone |
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