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Synthesis and post-synthetic derivatization of a cyanine-based amino acid. Application to the preparation of a novel water-soluble NIR dye |
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| Authors: | Bertrand Chipon Guillaume Clavé Cédric Bouteiller Marc Massonneau Anthony Romieu |
| Institution: | a IRCOF/LHO, Equipe de Chimie Bio-Organique, UMR 6014 CNRS, INSA de Rouen et Université de Rouen, 1, rue Tesnières, 76131 Mont-Saint-Aignan Cedex, France b QUIDD, Technopôle du Madrillet - ESIGELEC, Avenue Galilée, BP 10024, 76801 Saint Etienne du Rouvray, France |
| Abstract: | An efficient synthesis of a new fluorescent amino acid derived from a pentamethylene cyanine dye is described. Selective derivatization of its amino group with an original trisulfonated linker has led to a novel water-soluble NIR dye suitable for covalent labeling of biomolecules |
| Keywords: | Cyanine dye Fluorescent amino acid Sulfonation |
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