An expedient route to diaza-spirocycles utilizing a sequential multicomponent α-aminoallylation/ring-closing metathesis strategy |
| |
| Authors: | Vijaya Gracias Alan F Gasiecki Joel D Moore Irini Akritopoulou-Zanze Stevan W Djuric |
| |
| Institution: | Scaffold-Oriented Synthesis, Medicinal Chemistry Technologies, Abbott Laboratories, R4CP, AP10, 100 Abbott Park Road, Abbott Park, IL 60064-6099, USA |
| |
| Abstract: | A general method for the preparation of diaza-spirocycles is reported. This method used an olefin metathesis in order to construct the desired spirocyclic framework. Beginning with commercially available protected amino ketones, this strategy ultimately produced pharmacologically relevant diaza-scaffolds in an efficient and high-yielding process. |
| |
| Keywords: | |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
