Microwave-promoted Suzuki-Miyaura coupling of arylboronic acids with 1-bromo-2-naphthol, o-bromophenol, and o-chlorophenol |
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| Authors: | Piotr Wawrzyniak |
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| Affiliation: | Department of Chemistry and Biochemistry, Ernst-Moritz-Arndt-University Greifswald, 17487 Greifswald, Germany |
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| Abstract: | In this letter we report a simple and efficient way for the direct Suzuki-Miyaura cross-coupling of unprotected 2-hydroxyaryl bromides and of 2-chlorophenol with arylboronic acids using suitable phosphine/Pd(OAc)2 catalysts systems with moist K3PO4/toluene or moist CsF/dioxane and microwave heating (20 min 105 °C to 3 h 100-120 °C) with an internal temperature control providing 2-hydroxybiaryls in yields up to 98%. |
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| Keywords: | Hydroxybiaryl Suzuki cross-coupling Palladium catalyst Arylboronic acid Microwave |
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