Organocatalyzed asymmetric α-hydroxyamination of α-branched aldehydes: asymmetric synthesis of optically active N-protected α,α-disubstituted amino aldehydes and amino alcohols |
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Authors: | Sung-Gon Kim Tae-Ho Park |
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Affiliation: | Medicinal Science Division, Korea Research Institute of Chemical Technology, PO Box 107, Yuseong-gu, Daejeon 305-600, Republic of Korea |
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Abstract: | Enantioselective direct α-hydroxyamination and α-aminoxylation of α-branched aldehydes using a proline-derived tetrazole catalyst is described herein. α-Hydroxyamination adducts with up to 90% ee were obtained by the reaction of nitrosobenzene with unactivated α-branched aldehydes under mild reaction conditions. |
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Keywords: | Hydroxyamination Aminoxylation Asymmetric catalysis Organocatalysis |
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