Hybrid sugars as glycosidase inhibitors en route to 2-deoxy-2-amino C-glycosyl amino acids |
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Authors: | K Jayakanthan |
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Institution: | Department of Chemistry, Indian Institute of Technology, Kanpur 208 016, India |
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Abstract: | Sugar-azasugar hybrid molecules made up of d-galactose with nojirimycin-δ-lactam and pyrrolidine analogues are synthesized using intramolecular cyclization as a key step from 2-nitro galactal and found to be glycosidase inhibitors. Further, some of the intermediate compounds are converted into 2-deoxy-2-amino C-glycosyl glycines and C-glycosyl alanines. |
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