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1,1-Dihydroperoxycyclododecane as a new, crystalline non-hygroscopic oxidizer for the chemical synthesis of oligodeoxyribonucleotides |
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| Authors: | Hisao Saneyoshi Kohji Seio Mitsuo Sekine |
| Institution: | a Department of Life Science, Tokyo Institute of Technology, J2-12 4259 Nagatsuta, Midoriku, Yokohama, Kanagawa 226-8501, Japan b Division of Collaborative Research for Bioscience and Biotechnology, Frontier Collaborative Research Center, Japan c CREST, JST (Japan Science and Technology Agency) Nagatsuta, Midoriku, Yokohama 226-8501, Japan |
| Abstract: | A new oxidation method for DNA synthesis was developed by the use of 1,1-dihydroperoxycyclododecane in CH2Cl2-EtOAc under anhydrous conditions. This new oxidizer was successfully applied to the synthesis of oligodeoxyribonucleotides that involves an oxidation step for conversion of phosphite intermediates to phosphate derivatives. |
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