Constraint algebra for interacting quantum systems

We consider relativistic constrained systems interacting with external fields. We provide physical arguments to support the idea that the quantum constraint algebra should be the same as in the free quantum case. For systems with ordering ambiguities this principle is essential to obtain a unique quantization. This is shown explicitly in the case of a relativistic spinning particle, where our assumption about the constraint algebra plus invariance under general coordinate transformations leads to a unique S-matrix.