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| 高分子量的聚L-谷氨酸的合成与表征 | |
| 引用本文： | 曹田,尹静波,罗坤,陈红丹,陈学思. 高分子量的聚L-谷氨酸的合成与表征[J]. 高等学校化学学报, 2006, 27(2): 369-371 |
| 作者姓名： | 曹田 尹静波 罗坤 陈红丹 陈学思 |
| 作者单位： | 1. 上海大学材料学院高分子系, 上海 201800;2. 中国科学院长春应用化学研究所高分子物理与化学国家重点实验室, 长春 130022 |
| 基金项目： | 中国科学院资助项目;上海市教委资助项目;上海市科委资助项目 |
| 摘 要： | 采用三乙胺为催化剂经过氨基酸羧酸酐单体的开环聚合和脱保护基, 制备了高分子量聚L-谷氨酸. 实验结果表明, 合成的高分子量聚L-谷氨酸黏均分子量控制在70 000~350 000左右. 单体和引发剂的摩尔比n(A)/n(I)大于50时， 分子量与n(A)/n(I)无关. |
| 关 键 词： | L-谷氨酸 L-谷氨酸苄酯 聚-L-谷氨酸苄酯 聚-L-谷氨酸, |
| 文章编号： | 0251-0790（2006）02-0369-03 |
| 收稿时间： | 2005-02-21 |
| 修稿时间： | 2005-02-21 |
Synthesis and Characterization of Poly-L-glutamic Acid with a High Molecular Weight |
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| CAO Tian,YIN Jing-Bo,LUO Kun,CHEN Hong-Dan,CHEN Xue-Si. Synthesis and Characterization of Poly-L-glutamic Acid with a High Molecular Weight[J]. Chemical Research In Chinese Universities, 2006, 27(2): 369-371 | |
| Authors: | CAO Tian YIN Jing-Bo LUO Kun CHEN Hong-Dan CHEN Xue-Si |
| Affiliation: | 1. Department of Polymer, Shanghai University, Shanghai 201800, China; 2. State Key Laboratory of Polymer Physics and Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy Sciences, Changchun 130022, China |
| Abstract: | Abstract Poly-L-glutamic acid with a high molecular weight was prepared by chemical synthesis. The structures of PBLG and PLGA were confirmed by FTIR and 1H NMR spectroscopies and their molecular weights were measured by GPC and viscosity measurements. The results show that the average molecular weight of poly-L-glutamic acid is about 7×104_35×104. Furthermore, when the anhydride-initiator malar ratio n(A)/n(I)>50, the average molecular weight was independent of the amount of triethylamine initiator. |
| Keywords: | Keywords L-Glutamic acid γ-Benzyl L-glutamate Poly(γ-benzyl L-glutamate) Poly-L-glutamic acid |
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