Synthesis and spectral properties of some N-(2-benzimidazoyl)-α-aminoesters and their N-oxides

A series of new N-(2-benzimidazol)(S)-α-aminoesters and the respective N-oxides have been prepared, and their spectral data discussed. The CD spectra of the aliphatic and aromatic amino ester derivatives of either series show sign reversal for the observed Cotton effect (CE) band. This chiroptical behaviour was rationalized as due to differences in conformational isomerism.