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Antimykotisch wirksame Imidazolyl-alkene: Synthese und Röntgenstrukturanalyse von Omoconazol |
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| Authors: | Kurt Thiele Ludwig Zirngibl Max H. Pfenninger Martin Egli Max Dobler |
| Abstract: | Antimycotic Imidazolyl-alkenes: Synthesis and X-Ray Crystal Structure of Omoconazol The synthesis of omoconazol 4 from 2′,4′-dichloro-α-(1H-imidazol-1-yl)propiophenon ( 5 ) and 1-bromo-2-(4-chlorophenoxy)ethane ( 6 ) is described. Omoconazol, C20H17Cl3N2O2, crystallises in the monoclinic space group P21/n, a = 14.329, b = 8.703, c = 16.791 Å, β = 105.75°. The crystal structure showed that omoconazol has the (Z)-configuration, in accordance with previous NMR results. |
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