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Resolution of gossypol: Analytical and large-scale preparative HPLC on non-chiral phases |
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| Authors: | S. A. Matlin A. Belenguer R. G. Tyson A. N. Brookes |
| Abstract: | Racemic gossypol is resolved by HPLC of its amino acid ester Schiff's base derivatives on non-chiral columns. This provides a rapid and accurate method for determination of optical purity on a small scale and, combined with hydrolysis and fractional crystallization, for the preparation of pure gossypol enantiomers on a multi-gram scale. |
| Keywords: | Preparative HPLC Optical purity by HPLC Resolution of enantiomers (− )-Gossypol (+)-Gossypol |