Synthesis of 1,2-di-(4-pyridyl)ethylenediamine and related compounds |
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| Authors: | Miguel F. Bra a,Jos M. Castellano,Maria L. L pez Rodriguez,Magdalena G lvez,Manuel R. Amil,Enrique Rubio |
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| Affiliation: | Miguel F. Braña,José M. Castellano,Maria L. López Rodriguez,Magdalena Gálvez,Manuel R. Amil,Enrique Rubio |
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| Abstract: | Hydrolysis of N,N'-diacyl-1,2-di(4-pyridyl)ethylenediamines 1 in aqueous sulfuric acid gave the corresponding imidazolines 3. 1,2-Di-(4-pyridyl)ethylenediamine 2 was prepared in 61 % yield by treating N,N'-di-t-butyl-oxycarbonyl-1,2-di(4-pyridyl)ethylenediamine 4 with trifluoroacetic acid or in 94% yield by the hydrolysis under basic conditions of N,N'-diphthaloylglycyl-1,2-di(4-pyridy)ethylenediamine 13. |
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