PALLADIUM(0)-CATALYZED SYNTHESIS OF 2-PHENYL-2H-CHROMENE

ABSTRACT

2-Phenyl-2H-chromene is obtained in quite good yield starting from 3-(2-tert-butyldimethylsilyl)oxyphenyl]prop-2-enal. Condensation of this aldehyde with phenyl magnesium bromide, followed by the acetylation of the alcohol obtained, and then intramolecular cyclization in the presence of a palladium catalyst gave the phenylchromene in an overall 34% yield.