EASY LARGE-SCALE SYNTHESIS OF STERICALLY ENCUMBERED 2-IODOBIPHENYLS AND SOME DERIVATIVES THEREOF

The convenient one-pot reaction of o-bromofluorobenzene (1) with n-butyl lithium and aryl Grignard reagents followed by quenching with iodine affords substituted 2-iodobiphenyls (4) in yields of 45 to 71%. Lithiation of 4 followed by reaction with Me₂SiCl₂ affords the silanes ArSiMe₂Cl 7.