Nucleophilic Ring Enlargement of 2-Substituted-3-isothiazolones to 1,3-Thiazin-4-ones |
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Abstract: | Abstract 1,3-Thiazin-4-ones 9 and 10 have been prepared from the corresponding isothiazolones 7 and 8 by a clean and smooth reaction with tertiary amines at room temperature. This rearrangement is attributed to the abstraction of a methine proton from the 2-position isothiazolone substituent, followed by ring enlargement through cleavage of the S-N bond. |
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Keywords: | 3-Isothiazolones 1,3-Thiazin-4-ones Nucleophilic ring expansion Two phase reactions |
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