|
|||||
|
|
STABILITY-INDICATING METHODS FOR DETERMINATION OF MELOXICAM AND TENOXICAM IN THE PRESENCE OF THEIR DEGRADATION PRODUCTS |
|
| Abstract: | ABSTRACT A spectrophotometric and a spectrofluorimetric methods are developed for the determination of two nonsteroidal anti-inflammatory drugs meloxicam I and tenoxicam II in the presence of their degradation products, namely 5-methyl-2-aminothiazole (III), benzothiazine carboxylic acid (IV), for meloxicam, pyridine-2-amine (V) and methyl 4-hydroxy-2-methyl-2H-thienol[2,3-e]1,2-thiazine-3-carboxylate-1, 1-dioxide (VI) for tenoxicam, Fig. 1. STABILITY-INDICATING METHODS FOR DETERMINATION OF MELOXICAM AND TENOXICAM IN THE PRESENCE OF THEIR DEGRADATION PRODUCTS Published online:01 September 2006 Figure 1. The structure of the studied drugs and their degradation products. |
| Keywords: | Spectrophotometry Spectrofluorimetry quench-ing Stability-indicating method Determination of meloxicam and tenoxicam Drug formulations |