Sonogashira Coupling Reaction with Palladium Powder,Potassium Fluoride in Aqueous Media

Abstract

A Sonogashira coupling reaction of aromatic iodides and bromides with terminal alkynes in the presence of palladium powder, potassium fluoride, cuprous iodide, and triphenylphosphine in aqueous media was developed. The reaction generates the corresponding coupling products aryl alkynes in good to excellent yields.