Total Synthesis of (±)-Isocembrene: A Tactic for Both Diene Construction and Macrocycle Formation

Abstract

The total synthesis of (±)-isocembrene 1, a naturally occurring cembrene diterpenoid, has been achieved via a unified, convergent and highly efficient strategy by imploying an intramolecular Stille sp²–sp² macrocyclization as the key step and it presents an ideal opportunity to extend the effectiveness of the tactic for both 1,3-diene construction and macrocycle formation.