Enantioselective cis-β-lactam synthesis by intramolecular C–H functionalization from enoldiazoacetamides and derivative donor–acceptor cyclopropenes
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| Authors: | Xinfang Xu Yongming Deng David N Yim Peter Y Zavalij Michael P Doyle |
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| Institution: | a Key Laboratory of Organic Synthesis of Jiangsu Province , College of Chemistry , Chemical Engineering and Materials Science , Soochow University , Suzhou 215123 , China . Email: ; Tel: +86 0512 65883612 ;b Department of Chemistry and Biochemistry , University of Maryland , College Park , Maryland 20742 , USA . Email: |
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| Abstract: | β-Lactam derivatives are produced through intermediate donor–acceptor cyclopropene intermediates in high yield, exclusive cis-diastereoselectivity, and high enantiocontrol in a chiral dirhodium carboxylate catalyzed intramolecular C–H functionalization reaction of enoldiazoacetamides. |
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