| 以三乙酸甘油酯为底物制备光学活性戊醇的探索 |
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| 引用本文： | 孙琪,雷永诚,付超,宋航.以三乙酸甘油酯为底物制备光学活性戊醇的探索[J].化学研究与应用,2006,18(5):561-563. |
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| 作者姓名： | 孙琪 雷永诚 付超 宋航 |
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| 作者单位： | 四川大学化工学院制药与生物工程系,四川,成都,610065;四川大学化工学院制药与生物工程系,四川,成都,610065;四川大学化工学院制药与生物工程系,四川,成都,610065;四川大学化工学院制药与生物工程系,四川,成都,610065 |
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| 摘 要： | 1前言(S)-2-甲基-1-丁醇在手性精细化学品及药物合成中有重要的作用1]。从20世纪90年代起,国外的(R,S)-2-甲基-1-丁醇拆分方面做了一些有益的尝试。Ayter Sagiroglu等人利用固定化脂肪酶催化三丁酸甘油酯与(R,S)-2-甲基-1-丁醇发生不对称酯交换反应,可制备e.e.为98%的(S)-2-甲基-1-丁醇2]。同时我们的研究表明,无溶剂体系中,以猪胰脂肪酶或酵母脂肪酶为催化剂,三丁酸甘油酯为底物,拆分(R,S)-2-甲基-1-丁醇,可制备e.e.值大于90%的(S)-2-甲基-1-丁醇3]。采用三丁酸甘油酯,虽然所得产品e.e.较高,但其价格昂贵(1000元/kg)、反应周期较长…
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| 关 键 词： | 猪胰脂肪酶 三乙酸甘油酯 2-甲基-1-丁醇 |
| 文章编号： | 1004-1656（2006）05-0561-04 |
| 收稿时间： | 2005-06-10 |
| 修稿时间： | 2006-01-15 |
Preparation of optical active amyl alcohol by triacetin as substrate |
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| SUN Qi,LEI Yong-cheng,FU Chao,SONG Hang.Preparation of optical active amyl alcohol by triacetin as substrate[J].Chemical Research and Application,2006,18(5):561-563. |
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| Authors: | SUN Qi LEI Yong-cheng FU Chao SONG Hang |
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| Institution: | Department of Pharmaceutical and Biological Engineering,Sichuan University,Chengdu 610065 ,China |
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| Abstract: | Kinetic resolution of(R,S)-2-methyl-1-butanol was completed by porcine pancreatic lipase-catalyzed transesterification with triacetin in a solvent-free system.The effect of reaction conditions such as solvents,water,pH,temperature,and the molar ratio of the substrates on lipase activity and stereoselectivity were examined.The results demonstrate triacetin has an advantage of low price and high activity when it is employed as the substrate in the kinetic resolution of(R,S)-2-mentyl-1-butanol and is a very promising tributyrin substitute for industrial application. |
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| Keywords: | porcine pancreatic lipase triacetin 2-methyl-1-butanol |
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