Synthesis of 5-arylsubstituted thiazol-4-one acetyl and amino derivatives by the heterocyclization of the products of acrylamide thiocyanatoarylation

The heterocyclization of 2-thiocyanato-3-arylpropionamides in acetic anhydride followed by the deacylation of the intermediates formed in an alkaline medium afforded the otherwise difficultly accessible 2-amino-5-benzylthiazol-4-ones.