PIEZOELECTRIC PROPERTIES OF SINGLE-STRAND DNA MOLECULAR BRUSH BIOLAYERS |
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| Authors: | Zhang Nenghui Shan Jinying Xing Jingjing |
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| Affiliation: | 1. Shanghai Institute of Applied Mathematics and Mechanics, Shanghai University, Shanghai 200072, China;2. Department of Mechanics, College of Sciences, Shanghai University, Shanghai 200444, China;1. Department of Chemistry, University of Virginia, McCormick Road, Charlottesville, VA 22904, USA;2. Department of Pathology, University of Virginia Health Science Center, Charlottesville, VA 22908, USA;3. Department of Mechanical Engineering, University of Virginia, Engineer''s Way, Charlottesville, VA 22904, USA;1. Department of Dermatology, Venereology and Allergy, University Medical Center Mannheim, Ruprecht-Karls University of Heidelberg, Mannheim, Germany;2. Division of Immunogenetics, German Cancer Research Center, Heidelberg, Germany;3. Core Facility Tumor Models, German Cancer Research Center, Heidelberg, Germany;4. Department of Dermatology, Venereology and Allergy, University Medical Center Charité, Berlin, Germany;5. Institute of Pathology, University Medical Center Charité, Berlin, Germany;6. Department of Dermatology, Venereology and Allergy, HELIOS Klinikum, Krefeld, Germany;1. Shanghai Key Laboratory of Mechanics in Energy Engineering, Shanghai Institute of Applied Mathematics and Mechanics, Shanghai University, Shanghai 200072, China;2. Department of Mechanics, College of Sciences, Shanghai University, Shanghai 200444, China;1. Department of Radiology, Northwestern University, Chicago, Illinois;2. Robert H. Lurie Comprehensive Cancer Center, Northwestern University, Chicago, Illinois;3. Department of Biomedical Engineering, Northwestern University, Evanston, Illinois;4. Ocean Nanotech LLC, Springdale, Arizona;5. Department of Radiology and Radiological Sciences, Vanderbilt School of Medicine, 1611 21st Avenue South, CCC-1106 MCN, Nashville, TN 37232 |
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| Abstract: | The paper is devoted to investigations on nanomechanical behaviors of biochips in label-free biodetections.The chip consists of Si-layer,Ti-layer,Au-layer and single-strand DNA (ssDNA)molecular brush biolayer immobilized by self-assembly technology of thiol group.Unlike previous viewpoints,such as force-bending,entropy-bending and curvature electricity effect,etc., the piezoelectric effect of the biopolymer brush layer is viewed as the main factor that induces nanomechanical bending of biochips,and a classical macroscopic piezoelectric constitutive rela- tion is used to describe the piezoelectric effect.A new laminated cantilever beam model with a piezoelectric biolayer in continuum mechanics,the linearized Poisson-Boltzmann equation in statistical mechanics and the scaling method in polyelectrolyte brush theory are combined to es- tablish a relationship between the nanomechanical deflection of DNA chips and the factors such as nanoscopic structural features of ssDNA molecules,buffer salt concentration,macroscopic me- chanical/piezoelectric parameters of DNA chips etc.Curve fitting of experimental data shows that the sign of the piezoelectric constant of the biolayer may control the deflection direction of DNA chips during the packaging process. |
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| Keywords: | DNA chip laminated beam polymer brush piezoelectric effect |
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