Novel rhenium(I) polypyridine biotin complexes that show luminescence enhancement and lifetime elongation upon binding to avidin |
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Authors: | Lo Kenneth Kam-Wing Hui Wai-Ki Ng Dominic Chun-Ming |
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Affiliation: | Department of Biology and Chemistry, City University of Hong Kong, Tat Chee Avenue, Kowloon, P. R. China. bhkenlo@cityu.edu.hk |
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Abstract: | While most biotin-fluorophore conjugates suffer from significant emission quenching upon binding to avidin due to resonance energy-transfer, three novel rhenium(I) polypyridine biotin complexes have been designed in view of their characteristic photophysical properties, in particular their large Stokes shifts. In contrast to most biotin-fluorophore conjugates, the (3)MLCT emission intensities and lifetimes of these rhenium(I) complexes are increased upon binding to avidin, rendering them luminescent probes for avidin and biotinylated species. |
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