Determination of dicofol in aquatic products using molecularly imprinted solid-phase extraction coupled with GC-ECD detection |
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Authors: | Wang Hui Yan Hongyuan Qiu Mande Qiao Jindong Yang Gengliang |
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Affiliation: | a Key Laboratory of Pharmaceutical Quality Control of Hebei Province & College of Pharmacy, Hebei University, Baoding 071002, China b Key Laboratory of Medicinal Chemistry and Molecular Diagnosis, Hebei University, Baoding 071002, China |
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Abstract: | The novel molecularly imprinted microsphere (MIM) that could be applied as special sorbent was synthesized by aqueous suspension polymerization using 1,1-bis(4-chlorophenyl)-1,2,2,2-tetrachloroethane (α-chloro-DDT) as the dummy template. The obtained MIM exhibited good recognition and selectivity to dicofol and it was successfully applied as selective sorbent of solid-phase extraction for the determination of dicofol from aquatic products. At the optimum conditions of the molecularly imprinted solid-phase extraction (MISPE) coupled with GC-ECD, good linearity for dicofol was achieved in a range of 0.4-100 ng g−1 (r2 = 0.9995) and the recoveries at three spiked levels were ranged from 85.8% to 101.2% for aquatic products with the relative standard deviation (RSD) less than 5.6%. The presented MISPE-GC-ECD method exhibited the advantages of simplicity, selectivity and sensitivity, and could be potentially applied to the determination of dicofol in complicated aquatic products. |
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Keywords: | Molecularly imprinted microspheres Dummy template polymerization Solid-phase extraction Dicofol Aquatic products |
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