Voltammetric studies of the effect of Cisplatin-liposome on Hela cells |
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Authors: | Ci Y X Zhai Q Wang S Chang W B Zhang C Y Ma H Chen D Y Zhao M Z Hu S W |
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Institution: | Department of Chemistry, College of Chemistry and Molecular Engineering, Peking University, Beijing 100871, China. |
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Abstract: | In this paper, the voltammetric method was used for the first time to study the effect of Cisplatin-liposome on Hela cells. The results showed the voltammetric behavior of Hela cells was irreversible and the peak current had linear relationship with the cell number. With both Cisplatin-liposome concentration and treating time increasing, the peak current decreased. The peak current decreasing was in accordance with the nuclear damage and loss of mitochondrial membrane potential revealed by two-photon laser scanning microscopy and confocal laser scanning microscopy. This voltammetric method may provide a simple way to study the electron-transfer mechanism in drug-treating cells. |
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