Mapping of protein phosphatase-6 association with its SAPS domain regulatory subunit using a model of helical repeats |
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| Authors: | Julien Guergnon Urszula Derewenda Jessica R Edelson David L Brautigan |
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| Affiliation: | (1) Center for Cell Signalling, University of Virginia School of Medicine, Charlottesville, VA 22908, USA;(2) Department of Microbiology, University of Virginia School of Medicine, Charlottesville, VA 22908, USA;(3) Department of Molecular Physiology & Biological Physics, University of Virginia School of Medicine, Charlottesville, VA 22908, USA |
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| Abstract: | Background Helical repeat motifs are common among regulatory subunits for type-1 and type-2A protein Ser/Thr phosphatases. Yeast Sit4 is a distinctive type-2A phosphatase that has dedicated regulatory subunits named Sit4-Associated Proteins (SAPS). These subunits are conserved, and three human SAPS-related proteins are known to associate with PP6 phosphatase, the Sit4 human homologue. |
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