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Glycal-ruthenium carbonyl clusters: Syntheses, characterization, and anticancer activity |
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| Authors: | V.D. Reddy Divya Dayal M.V. Ramana Reddy Richard D. Adams |
| Affiliation: | a Department of Physical Sciences, Kingsborough College of The City University of New York, 2001 Oriental Blvd., Brooklyn, NY 11235, United States b Stuyvesant High School, 345 Chambers Street, New York, NY 10282, United States c Fels Institute for Cancer Research, Temple University School of Medicine, 3307 North Broad Street, Philadelphia, PA 19140, United States d Department of Chemistry and Biochemistry, University of South Carolina, Columbia, SC 29208, United States |
| Abstract: | Four new chiral ruthenium carbonyl cluster complexes Ru3(μ-H)2(CO)9(L-2H) (1), Ru3(μ-H)2(CO)7(L-2H)(dppm) (2), Ru3(μ-H)2(CO)7(L-2H)(PPh3)2 (3), Ru3(μ-H)2(CO)7(L-2H)(dppe) (4) containing a dehydrogenated form (L-2H) of 3,4,6-tri-O-benzyl-d-galactal (L) as a chiral ligand have been prepared and characterized. The anticancer activity of five compounds 1-4 and Ru3(μ-H)2(CO)9(L-2H) 5 (L = tribenzyl glucal) against six types of human cancer cell lines was studied and compared to cisplatin. Compound 1 was chosen to produce more detailed growth curves based on overall highest activity profile. The structure of compound 2 was established by a single-crystal X-ray diffraction analysis. The structure based on triangular metal framework contains a bridging dehydrogenated tribenzyl galactal ligand bonded in a parallel μ3-η2-bonding mode and a bridging dppm ligand. Variable-temperature NMR studies show that the two hydride ligands in compounds 1 and 2 are dynamically active on the NMR time scale at room temperature. |
| Keywords: | Anticancer agents Glycal Ruthenium Bioorganometallic chemistry Hydride ligands |
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