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Enantiospecific synthesis of tetrasubstituted δ-lactones |
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| Authors: | Annabel L. Wilkinson Ulf Hanefeld Barrie Wilkinson Peter F. Leadlay James Staunton |
| Affiliation: | a University Chemical Laboratory and Cambridge Centre for Molecular Recognition, Lensfield Road, Cambridge CB2 1EW, UK b Department of Biochemistry and Cambridge Centre for Molecular Recognition, 80 Tennis Court Road, Cambridge CB2 1GA, UK |
| Abstract: | For investigations concerning the selectivity of polyketide synthases (PKSs) which have been rationally engineered through genetic techniques the synthesis of substituted δ-lactones is of great importance. An enantiospecific route towards eight of the possible sixteen stereoisomers was developed which is also readily adaptable for the introduction of alkyl modifications and isotopic labels. |
| Keywords: | Aldol reaction Asymmetric synthesis Lactones Polyketides Combinatorial Biosynthesis |
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