Histidinylated linear PEI: a new efficient non-toxic polymer for gene transfer |
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| Authors: | Bertrand Emilie Gonçalves Cristine Billiet Ludivine Gomez Jean Pierre Pichon Chantal Cheradame Hervé Midoux Patrick Guégan Philippe |
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| Affiliation: | Laboratoire LAMBE équipe MPI, UMR 8587, Université d'Evry Val d'Essonne, Evry, France. |
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| Abstract: | A series of linear polyethylenimine (lPEI) substituted with histidine residue (His-lPEI) was synthesized using the Michael reaction in order to provide new highly efficient vectors for gene therapy applications (up to 95% of transfected cells) with remarkable low cytotoxicity compared to lPEI-based polyplexes. |
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