BF2-azadipyrromethenes: probing the excited-state dynamics of a NIR fluorophore and photodynamic therapy agent |
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Authors: | Batat Pinar Cantuel Martine Jonusauskas Gediminas Scarpantonio Luca Palma Aniello O'Shea Donal F McClenaghan Nathan D |
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Institution: | University of Bordeaux/CNRS, Institut des Sciences Moléculaires, 351, crs de la Libération, 33405 Talence, France. |
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Abstract: | BF(2)-Azadipyrromethene dyes are a promising class of NIR emitter (nonhalogenated) and photosensitizer (halogenated). Spectroscopic studies on a benchmark example of each type, including absorption (one and two photon), time-resolved transient absorption (ps-ms) and fluorescence, are reported. Fast photodynamics reveal that intense nanosecond NIR fluorescence is quenched in a brominated analog, giving rise to a persistent (21 μs) transient absorption signature. Kinetics for these changes are determined and ascribed to the efficient population of a triplet state (72%), which can efficiently sensitize singlet oxygen formation (ca. 74%), directly observed by (1)Δ(g) luminescence. Photostability measurements reveal extremely high stability, notably for the nonhalogenated variant, which is at least 10(3)-times more stable (Φ(photodeg.) = < 10(-8)) than some representative BODIPY and fluorescein dyes. |
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