| I2负载蒙脱土超声法催化Biginelli反应 |
| |
| 引用本文： | 尹晓刚,吴小云,王野,陈治明,陈卓. I2负载蒙脱土超声法催化Biginelli反应[J]. 化学通报, 2016, 79(9): 834-838 |
| |
| 作者姓名： | 尹晓刚 吴小云 王野 陈治明 陈卓 |
| |
| 作者单位： | 贵州师范大学化学与材料科学学院,贵州师范大学化学与材料科学学院,贵州师范大学化学与材料科学学院,贵州师范大学化学与材料科学学院,贵州师范大学化学与材料科学学院 |
| |
| 基金项目： | 国家自然(NO.21362006)；贵州省科学技术,黔科合J字[2014]2129号 |
| |
| 摘 要： | 以芳香醛、乙酰乙酸乙酯及脲为原料,I2负载蒙脱土为催化剂,对超声条件下Biginelli反应进行研究。用单因素法考察溶剂及催化剂对产率的影响,通过正交试验优化温度、超声时间及原料摩尔比。优化反应条件为:反应温度80℃,超声时间5min,芳香醛、乙酰乙酸乙酯和脲的摩尔比为1∶1∶1,催化剂用量为10(mol)%,产率最高可达86.9%。合成的7种3,4-二氢嘧啶-2(1H)-酮衍生物的结构通过红外光谱、核磁共振氢谱和熔点进行表征。
|
| 关 键 词： | 蒙脱土 I2 超声 Biginelli反应 |
| 收稿时间： | 2016-01-07 |
| 修稿时间： | 2016-03-13 |
Biginelli reaction catalysized by I2 loaded montmorillonite under ultrasonic conditions |
| |
| Yin Xiao-gang,Wu Xiao-yun,Wang Ye,Chen Zhi-ming and Chen Zhuo. Biginelli reaction catalysized by I2 loaded montmorillonite under ultrasonic conditions[J]. Chemistry, 2016, 79(9): 834-838 |
| |
| Authors: | Yin Xiao-gang Wu Xiao-yun Wang Ye Chen Zhi-ming Chen Zhuo |
| |
| Affiliation: | Key Laboratory of Functional Materials Chemistry of Gui Zhou Province,School of Chemistry and Materials Science,Gui Zhou Normal University,Key Laboratory of Functional Materials Chemistry of Gui Zhou Province,School of Chemistry and Materials Science,Gui Zhou Normal University,Key Laboratory of Functional Materials Chemistry of Gui Zhou Province,School of Chemistry and Materials Science,Gui Zhou Normal University,Key Laboratory of Functional Materials Chemistry of Gui Zhou Province,School of Chemistry and Materials Science,Gui Zhou Normal University,Key Laboratory of Functional Materials Chemistry of Gui Zhou Province,School of Chemistry and Materials Science,Gui Zhou Normal University |
| |
| Abstract: | An ultrasound-assisted biginelli reaction catalysized by I2 loaded montmorillonite was developed using ethylacetoacetate,aromaticaldehyde and urea as starting material. Influences of solvents,catalysts, quivalency of starting materials on yields were investigated using single factor methods and the temperature, ultrasonic time were investigated using orthogonal tests. Under the optimized conditoins, yields of 3,4-Dihydropyrimidin-2(1H)ones derivatives up to 86.9%. The products were characterized by 1H NMR,IR and M.P. |
| |
| Keywords: | montmorillonite I2 Ultrasonic assisted Biginelli reaction |
| 本文献已被 CNKI 等数据库收录！ |
| 点击此处可从《化学通报》浏览原始摘要信息 |
|
点击此处可从《化学通报》下载全文 |
|
