Synthesis and binding properties of guanidinium biscarboxylates |
| |
Authors: | Andreas Sp?th Janina Gonschor and Burkhard K?nig |
| |
Institution: | (1) Institut f?r Organische Chemie, Universit?t Regensburg, 93040 Regensburg, Germany |
| |
Abstract: | Abstract The ammonium ion binding site of the enzyme glutaminase HisF inspired us to design guanidinium biscarboxylates as potential
self-organized ionophores in molecular recognition. The syntheses of the title compounds based on aliphatic and aromatic building
blocks, along with a general method for the preparation of δ-aminoethoxyacetic acids, are presented in this work. Investigation
of the binding properties of the title compounds in dimethyl sulfoxide (DMSO) and methanol solution revealed no ammonium ion
affinity, but interaction of the guanidinium moiety with acetate ions. |
| |
Keywords: | |
本文献已被 SpringerLink 等数据库收录! |
|