| 核壳型二氧化硅色谱填料的研究进展 |
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| 引用本文： | 夏红军,刘家玮,白泉. 核壳型二氧化硅色谱填料的研究进展[J]. 色谱, 2020, 38(4): 372-382. DOI: 10.3724/SP.J.1123.2019.08014 |
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| 作者姓名： | 夏红军 刘家玮 白泉 |
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| 作者单位： | 1. 教育部天然与功能分子化学重点实验室,西北大学现代分离科学研究所,陕西省现代分离科学重点实验室, 西北大学,陕西 西安 7100692. 河南省稀土功能材料重点实验室,周口师范学院,河南 周口 466000 |
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| 基金项目： | 国家自然科学基金项目(21874106);国家自然科学基金项目(21545007);国家自然科学基金项目(21605122);陕西省自然科学基金(2018JZ2001);陕西省自然科学基金(2018JQ2011) |
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| 摘 要： | 复杂样品的高效快速分离分析是分离科学家所面临的挑战。近年来,核壳型二氧化硅色谱填料以其高效、快速和低背压的特点被广泛用于小分子、大分子和复杂样品的快速分离分析。该文系统综述了二氧化硅核壳色谱固定相快速分离的机理,制备方法及其在小分子、多肽和生物大分子快速分离分析方面的应用,同时对核壳型色谱固定相的发展进行了展望。
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| 关 键 词： | 核壳型色谱固定相 高效液相色谱 快速分离分析 综述 |
| 收稿时间： | 2019-08-19 |
Research progress on core-shell silica stationary phases for high performance liquid chromatography |
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| XIA Hongjun,LIU Jiawei,BAI Quan. Research progress on core-shell silica stationary phases for high performance liquid chromatography[J]. Chinese journal of chromatography, 2020, 38(4): 372-382. DOI: 10.3724/SP.J.1123.2019.08014 |
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| Authors: | XIA Hongjun LIU Jiawei BAI Quan |
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| Affiliation: | 1. Key Laboratory of Synthetic and Natural Functional Molecule Chemistry of Ministry of Education, Institute of Modern Separation Science, Key Lab of Modern Separation Science in Shaanxi Province, Northwest University, Xi’an 710069, China2. Henan Key Laboratory of Rare Earth Functional Materials, Zhoukou Normal University, Zhoukou 466000, China |
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| Abstract: | Fast and efficient separation by using high performance liquid chromatography (HPLC) is challenging for a wide range of samples. In recent years, core-shell silica microspheres have been widely investigated and used for highly efficient and fast separation under reasonably low pressure for small solutes, biopolymers, and complex samples. In this paper, the mechanism for fast separation and preparation methods of core-shell silica microspheres are introduced, along with their application for HPLC-based separation of small molecules, peptides, and biological macromolecules in HPLC. The developing trends of using core-shell microspheres in HPLC are also presented. |
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| Keywords: | core-shell silica microspheres high performance liquid chromatography (HPLC) fast separation and analysis review |
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