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| 三核镍配合物Ni_3(C_(14)H_8N_3O_5)_2(C_5H_5N)_4的合成、晶体结构和抗癌活性(英文) | |
| 作者姓名： | 仇晓阳 徐茂田 朱海亮 刘伟生 赵文献 |
| 作者单位： | 1. 商丘师范学院化学系,商丘,476000;南京大学医药生物技术国家重点实验室,南京,210093 2. 商丘师范学院化学系,商丘,476000 3. 南京大学医药生物技术国家重点实验室,南京,210093 4. 兰州大学应用有机化学国家重点实验室,兰州,730000 |
| 基金项目： | 国家自然科学基金项目，河南省教育厅项目，安徽省教育厅项目 |
| 摘 要： | The title complex Ni3(C14H8N3O5)2(C5H5N)4 has been synthesized by the reaction of 2-hydroxy-N′-(4- nitrobenzoyl)benzohydraizide with nickel acetate in pyridine solution. Its molecular structure was characterized by elemental analysis, IR spectra and X-ray crystal structure determination. Crystal data for this compound: Mono- clinic, space group P21/c, Mr=1 089.00, a=0.249 27(5) nm, b=0.161 40(3) nm, c=0.121 81(2) nm, β=94.59(3)°, V= 4.885 2(17) nm3, Z=4, Dc=1.481 Mg·m-3, F(000)=2 232, R1=0.049 7, wR2=0.106 8 (observed reflections with I2σ(I)) and R1=0.105 1, wR2=0.119 4 (all reflections), GOF=1.021. The complex was evaluated for their antitumor activi- ties against two kinds of cell lines (K562 and BGC) by MTT method. A preliminary bioactivity study indicates that the complex shows distinct antitumor activity. |
| 关 键 词： | 镍配合物 合成 晶体结构 抗癌活性 Ni(Ⅱ) complex |
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