Gould-Jacobs reaction of 6-amino-2,3-diphenylquinoxaline |
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| Authors: | V. Milata D. Ilavsky M. Chudík Ľ. Zalibera J. Leško M. Seman A. Belicova |
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| Affiliation: | (1) Department of Organic Chemistry, Slovak Technical University, SK-81237 Bratislava;(2) Central Laboratory of Chemical Technique, Faculty of Chemical Technology, Slovak Technical University, SK-81237 Bratislava;(3) Institute of Cells Biology, Faculty of Natural Sciences, Comenius University, SK-81107 Bratislava |
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| Abstract: | Summary Catalytic hydrogenation of 2,3-diphenyl-6-nitroquinoxaline led to the corresponding amine1 which in turn afforded products3a-i on reaction with alkoxymethylene derivatives2a-i. Thermal cyclization of3b and3f yielded substituted pyrazinoquinolones5b and5f, respectively. Optimal conditions for the successful hydrolysis of ester5b were found. The structures of all products were deduced from their IR, UV,1H, and13C NMR spectroscopic data.Dedicated to Prof.F. Sauter on the occasion of his 65th birthday |
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| Keywords: | Pyrazinoquinolones Quinoxalinoaminoethylenes 6-Aminoquinoxalines 1H and13C NMR Biological activity |
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