Probing the reaction mechanism of aristolochene synthase with 12,13-difluorofarnesyl diphosphate |
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| Authors: | Yu Fanglei Miller David J Allemann Rudolf K |
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| Affiliation: | School of Chemistry, Cardiff University, Main Building, Park Place, Cardiff, UK CF10 3AT. |
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| Abstract: | 12,13-Difluorofarnesyl diphosphate, prepared using Suzuki-Miyaura chemistry, is a potent inhibitor of aristolochene synthase (AS), indicating that the initial cyclisation during AS catalysis generates germacryl cation in a concerted reaction. |
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