Four New Benzoylamide Derivatives Isolated from the Seeds of Lepidium apetalum Willd. and Ameliorated LPS-Induced NRK52e Cells via Nrf2/Keap1 Pathway |
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| Authors: | Meng Li Beibei Zhang Mengnan Zeng Jingke Zhang Zhiguang Zhang Weisheng Feng Xiaoke Zheng |
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| Institution: | 1.College of Pharmacy, Henan University of Chinese Medicine, Zhengzhou 450046, China; (M.L.); (B.Z.); (M.Z.); (J.Z.); (Z.Z.);2.The Engineering and Technology Center for Chinese Medicine Development of Henan Province, Zhengzhou 450046, China |
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| Abstract: | Four new benzoylamide derivatives, lepidiumamide B–E (1–4), were isolated from the seeds of Lepidium apetalum Willd. The structures were determined by a combination of MS and NMR analyses. All compounds were evaluated for their protective effects against NRK-52e cell injury induced by lipopolysaccharide (LPS) in vitro. These compounds showed significantly protective activity and ameliorated LPS-induced NRK52e cells via the Nrf2/Keap1 pathway. The discovery of these active compounds is important for the prevention and treatment of renalinjury. |
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| Keywords: | Lepidium apetalum Willd seeds benzoylamide derivatives NRK-52e cell LPS Nrf2/Keap1 pathway |
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