首页 | 本学科首页   官方微博 | 高级检索  
     检索      


Application of a column selection system and DryLab software for high-performance liquid chromatography method development
Authors:Krisko Ryan M  McLaughlin Kieran  Koenigbauer Michael J  Lunte Craig E
Institution:Department of Chemistry, University of Kansas, Mallott Hall, Lawrence, KS 66045, USA.
Abstract:This paper describes a strategy for the development of chromatographic methods for drug candidates based upon the use of simple MS compatible mobile phases and optimization of the chromatographic selectivity through variations of the stationary phase and mobile phase pH. The strategy employs an automated column selection system and a series of HPLC columns, varying in hydrophobicity and silanol activity, in combination with DryLab software to develop chromatographic methods for the separation of mixtures of bupivacaine and its metabolites; acidic, basic, and neutral compounds; and atenolol, nitrendipine, and their degradation products.
Keywords:
本文献已被 PubMed 等数据库收录!
设为首页 | 免责声明 | 关于勤云 | 加入收藏

Copyright©北京勤云科技发展有限公司  京ICP备09084417号