| A practical stereoselective synthesis of (S)-( - )-ofloxacin |
| |
| 引用本文： | 杨玉社,嵇汝运,陈凯先. A practical stereoselective synthesis of (S)-( - )-ofloxacin[J]. 中国化学, 1999, 17(5): 539-544. DOI: 10.1002/cjoc.19990170516 |
| |
| 作者姓名： | 杨玉社 嵇汝运 陈凯先 |
| |
| 作者单位： | YANG，Yu-She JI，Ru-Yun CHEN，Kai-XianShanghai Institute of Materia Medica，Chinese Academy of Sciences，Shanghai 200031，China |
| |
| 基金项目： | National Natural Science Foundtion of China. |
| |
| 摘 要： | A very efficient and practical procedure for preparation of ( S)-( - )-ofloxacin has been developed (10 steps, overall yield ≥ 45 % ) . The key step of this approach is the regioselective nucleophilic substitution of 2-position fluorine atom of 2,3,4-tirfluoronitrobenzene by (S)-glycerol acetonide.
|
A practical stereoselective synthesis of (S)-( - )-ofloxacin |
| |
| YANG,Yu-She JI,Ru-Yun CHEN,Kai-Xian. A practical stereoselective synthesis of (S)-( - )-ofloxacin[J]. Chinese Journal of Chemistry, 1999, 17(5): 539-544. DOI: 10.1002/cjoc.19990170516 |
| |
| Authors: | YANG Yu-She JI Ru-Yun CHEN Kai-Xian |
| |
| Affiliation: | YANG,Yu-She JI,Ru-Yun CHEN,Kai-XianShanghai Institute of Materia Medica,Chinese Academy of Sciences,Shanghai 200031,China |
| |
| Abstract: | A very efficient and practical procedure for preparation of ( S)-( - )-ofloxacin has been developed (10 steps, overall yield ?45%). The key step of this approach is the regioselective nucleophilic substitution of 2-position fluorine atom of 2,3,4 tirfluoronitrobenzene by (S)-glycerol acetonide. |
| |
| Keywords: | (S)-( - )-Ofloxacin stereoselective synthesis quinolone antibacterial agent. |
| 本文献已被 CNKI 等数据库收录！ |
