Application of Reductive Samariation to the Synthesis of Small Unnatural Peptides |
| |
Authors: | Ricci Madariaga Skrydstrup |
| |
Affiliation: | Department of Chemistry University of Aarhus Langelandsgade 140, 8000 Aarhus C (Denmark). |
| |
Abstract: | Considering that the amide NH groups are neither protected nor deprotonated, reductive samariation in the presence of a carbonyl substrate is a remarkably efficient method for the formation of a C-C bond. This was shown for a series of dipeptides and a tripeptide [Eq. (a)]. For the latter the product was obtained in a good yield of 50 %, despite the presence of three amide protons. |
| |
Keywords: | |
本文献已被 PubMed 等数据库收录! |
|