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Synthesis of 2-Substituted and 2,3-Disubstituted Quinazolin-4-ones Containing a Sterically Hindered Phenol Residue |
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| Authors: | V. I. Kelarev M. A. Silin V. N. Koshelev O. A. Borisova |
| Affiliation: | (1) I. M. Gubkin Russian State Oil and Gas University, Moscow, 117917; himeko@dol.ru |
| Abstract: | A series of 2-substituted and 2,3-disubstituted quinazolin-4-ones containing a 3,5-di(tert-butyl)-4-hydroxyphenyl group has been synthesized. They were prepared by the condensation of carboxylic acid imino ester hydrochlorides containing the indicated fragment with ethyl anthranilate and also by the reaction of azomethines, N-acylhydrazones, or the 4-phenylthiosemicarbazone of 3,5-di(tert-butyl)-4-hydroxybenzaldehyde with 2-methyl-4H-2,1-benzoxazin-4-one. |
| Keywords: | azomethines N-acylhydrazones carboxylic acid imino esters sterically hindered phenols thiosemicarbazones quinazolin-4-ones condensation |
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