One-pot esterification and Ritter reaction: chemo- and regioselectivity from tert-butyl methyl ether |
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| Authors: | Pankaj DawarM. Bhagavan Raju Ramesha A. Ramakrishna |
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| Affiliation: | a R L Fine Chem. No. 15, KHB Industrial Area, Yelahanka Newtown, 560106 Bangalore, India
b CM College of Pharmacy, Maisammaguda, Dhullapally (post Via), Hakeempet, Rangareddy, Secunderabad 500 014, India |
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| Abstract: | tert-Butyl methyl ether (TBME) has been effectively used as a reagent for esterification of carboxylic acids. By varying amounts of sulfuric acid, a remarkable regioselectivity in esterification has been demonstrated. Additionally, under the present reaction conditions, one-pot esterification and Ritter reaction are achieved in almost quantitative yield. |
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| Keywords: | Esterification Ritter reaction TBME Regioselective Chemoselective |
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