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Multi-components of T2 relaxation in ex vivo cartilage and tendon
Authors:ShaoKuan Zheng  Yang Xia  
Institution:aDepartment of Physics and Center for Biomedical Research, Oakland University, Rochester, MI 48309, USA
Abstract:The multi-components of T2 relaxation in cartilage and tendon were investigated by microscopic MRI (μMRI) at 13 and 26 μm transverse resolutions. Two imaging protocols were used to quantify T2 relaxation in the specimens, a 5-point sampling and a 60-point sampling. Both multi-exponential and non-negative-least-square (NNLS) fitting methods were used to analyze the μMRI signal. When the imaging voxel size was 6.76 × 10−4 mm3 and within the limit of practical signal-to-noise ratio (SNR) in microscopic imaging experiments, we found that (1) canine tendon has multiple T2 components; (2) bovine nasal cartilage has a single T2 component; and (3) canine articular cartilage has a single T2 component. The T2 profiles from both 5-point and 60-point methods were found to be consistent in articular cartilage. In addition, the depletion of the glycosaminoglycan component in cartilage by the trypsin digestion method was found to result in a 9.81–20.52% increase in T2 relaxation in articular cartilage, depending upon the angle at which the tissue specimen was oriented in the magnetic field.
Keywords:Multi-component  T2  Articular cartilage  Bovine nasal cartilage  Tendon  MRI  Trypsin digestion  Magic angle effect
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