The New Macromolecular Femtosecond Crystallography (MFX) Instrument at LCLS |
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| Authors: | Sébastien Boutet Aina E Cohen Soichi Wakatsuki |
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| Institution: | 1. Linac Coherent Light Source, SLAC National Accelerator Laboratory, Menlo Park, California, USA;2. Stanford Synchrotron Radiation Lightsource, SLAC National Accelerator Laboratory, Menlo Park, California, USA;3. Bioscience Division, SLAC National Accelerator Laboratory, Menlo Park, California, USA;4. Structural Biology, School of Medicine, Stanford University, Stanford, California, USA |
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| Abstract: | Macromolecular X-ray crystallography has developed, since its first use over 50 years ago to solve the structure of myoglobin, into a widely used method with broad impact in biological sciences and in society. It is today the primary technique used to obtain structural information on biomolecules that can shed light on their function and this information is often used in biomedical applications such as drug design. As this article is written, the Protein Data Bank 1 F.C. Bernstein, Journal of Molecular Biology 112(3), 535–542 (1977).Crossref], PubMed], Web of Science ®] , Google Scholar]] has just reached the milestone of 100,000 deposited X-ray structures, with a continuing trend for an ever-increasing number of structures every year. The primary contribution to this success and the increasing number of X-ray structures is the broad availability of synchrotron radiation sources with many dedicated beamlines around the world providing rapid and efficient data collection along with standard data analysis tools capable of fast data interpretation. |
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