Combinatorial synthesis of heterocycles: solid-phase synthesis of 2-amino-4(1H)-quinazolinone derivatives |
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Authors: | Gopalsamy A Yang H |
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Institution: | Chemical Sciences Division, Wyeth-Ayerst Research, Pearl River, New York 10965, USA. |
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Abstract: | A new solid-phase synthesis of various substituted 2-amino-4(1H)-quinazolinones from a resin bound amine component is described. The amine was readily converted to the corresponding polymer bound S-methylthiopseudourea. Condensation with different substituted isatoic anhydrides afforded 2-amino-4(1H)-quinazolinone derivatives. The method is amenable for combinatorial library generation. |
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